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Disease Reports

Company ReportsHalozyme Therapeutics

Halozyme Therapeutics(HALO)

Halozyme Therapeutics is an American biotechnology company that develops novel oncology therapies designed to target the tumor microenvironment and licenses a novel drug delivery technology through corporate partnerships.

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Hylenex recombinant	Hyaluronidase (human recombinant)	2005-12-02		Rheumatoid arthritis , Mantle-cell lymphoma , B-cell lymphoma , Lymphoid leukemia , Granulomatosis with polyangiitis , Microscopic polyangiitis

Clinical Trials

Therapeutic Areas:

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Classification:

All

Approval:

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Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Hyaluronidase (human recombinant)

non-hodgkin lymphoma

,

b-cell lymphoma

,

multiple myeloma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

prostatic neoplasms

,

,

,

breast neoplasms

,

ovarian neoplasms

,

pancreatic neoplasms

,

,

ovarian epithelial carcinoma

,

,

cutaneous malignant melanoma

,

non-small-cell lung carcinoma

,

Hyaluronate sodium

Polytetrafluoroethylene

liver neoplasms

shy-drager syndrome

,

multiple system atrophy

,

lewy body disease

,

,

synucleinopathies

,

,

,

chronic hepatitis

,

invasive hydatidiform mole

,

hematologic diseases

,

immunoblastic lymphadenopathy

,

,

,

myxoid liposarcoma

,

immunologic deficiency syndromes

,

pharyngeal neoplasms

,

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

bone marrow diseases

,

b-cell leukemia

,

biphenotypic leukemia acute

,

gata2 deficiency

,

,

aids-related lymphoma

,

,

pharmacokinetics

,

communicable diseases

,

dna repair-deficiency disorders

,

mediastinal neoplasms

,

t-cell antigen receptor specificity

,

,

,

olfactory esthesioneuroblastoma

,

appendiceal neoplasms

,

hyperbaric oxygenation

,

meningeal neoplasms

,

experimental neoplasms

,

herpesviridae infections

,

carcinoma in situ

,

,

,

otorhinolaryngologic neoplasms

,

ductal carcinoma

,

testicular neoplasms

,

rectal diseases

,

,

vesicular stomatitis

,

,

,

parkinson disease

,

b-cell lymphoma

,

,

castration-resistant prostatic neoplasms

,

pancreatic ductal carcinoma

,

gastrointestinal neoplasms

,

,

digestive system neoplasms

,

follicular lymphoma

,

,

female genital neoplasms

,

endometrioid carcinoma

,

mouth neoplasms

,

adenocarcinoma of lung

,

small cell carcinoma

,

basal cell neoplasms

,

oropharyngeal neoplasms

,

extranodal nk-t-cell lymphoma

,

basal cell carcinoma

,

neuroendocrine carcinoma

,

drug-related side effects and adverse reactions

,

,

gastrointestinal stromal tumors

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

myelodysplastic syndromes

,

,

chronic hepatitis b

,

meningeal carcinomatosis

,

penile neoplasms

,

thymus neoplasms

,

anaplastic thyroid carcinoma

,

salivary gland neoplasms

,

,

adenoid cystic carcinoma

,

hemangiosarcoma

,

disease progression

,

malignant fibrous histiocytoma

,

glandular and epithelial neoplasms

,

ureteral neoplasms

,

second primary neoplasms

,

,

,

b-cell chronic lymphocytic leukemia

,

adrenocortical carcinoma

,

mantle-cell lymphoma

,

,

urethral neoplasms

,

residual neoplasm

,

mycosis fungoides

,

b-cell lymphoma marginal zone

,

lymphoid leukemia

,

,

vulvar neoplasms

,

,

,

acquired immunodeficiency syndrome

,

,

adenoviridae infections

,

,

waldenstrom macroglobulinemia

,

t-cell lymphoma cutaneous

,

urogenital neoplasms

,

unknown primary neoplasms

,

serous cystadenocarcinoma

,

tracheal neoplasms

,

,

synovial sarcoma

,

,

oligodendroglioma

,

,

,

portal hypertension

,

,

progression-free survival

,

reactive arthritis

,

large-cell lymphoma anaplastic

,

pheochromocytoma

,

perivascular epithelioid cell neoplasms

,

burkitt lymphoma

,

alveolar soft part sarcoma

,

urinary bladder diseases

,

spinocerebellar degenerations

,

,

diffuse intrinsic pontine glioma

,

,

,

pelvic neoplasms

,

inflammatory breast neoplasms

,

,

,

nervous system diseases

,

,

therapeutic chemoembolization

,

liver transplantation

,

,

soft tissue neoplasms

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

inborn genetic diseases

,

,

gestational trophoblastic disease

,

clear cell adenocarcinoma

,

adenomyoepithelioma

,

,

local neoplasm recurrence

,

,

bites and stings

,

mucinous adenocarcinoma

,

,

,

parathyroid neoplasms

,

neurofibrosarcoma

,

trophoblastic neoplasms

,

paranasal sinus neoplasms

,

,

extramammary paget disease

,

,

environmental biomarkers

,

abdominal neoplasms

,

,

medulloblastoma

,

,

spinal cord neoplasms

,

lymphoproliferative disorders

,

positron emission tomography computed tomography

,

urologic diseases

,

kidney diseases

,

vaginal neoplasms

,

induction chemotherapy

,

multiple primary neoplasms

,

,

rhabdomyosarcoma

,

central nervous system neoplasms

,

venous thrombosis

,

,

,

,

tertiary lymphoid structures

,

adrenal gland neoplasms

,

,

clear cell sarcoma

,

tumor virus infections

,

genetic therapy

,

microsatellite repeats

,

organ preservation

,

myeloid leukemia chronic-phase

,

,

smoldering multiple myeloma

,

cystadenocarcinoma

,

,

desmoplastic small round cell tumor

,

mucinous cystadenocarcinoma

,

,

bronchiolo-alveolar adenocarcinoma

,

islet cell carcinoma

,

choriocarcinoma

,

,

sex cord-gonadal stromal tumors

,

mesothelial neoplasms

,

acinar cell carcinoma

,

,

mesodermal mixed tumor

,

giant cell carcinoma

,

,

pseudomyxoma peritonei

,

spinal neoplasms

,

hypertrophic pyloric stenosis

,

treatment outcome

,

,

coronavirus infections

,

,

viral pneumonia

,

multiple pulmonary nodules

,

prostatic diseases

,

precancerous conditions

,

bronchopulmonary dysplasia

,

tobacco smoking

,

choroid plexus neoplasms

,

,

adrenal cortex neoplasms

,

adenosquamous carcinoma

,

leukoencephalopathies

,

progressive multifocal leukoencephalopathy

,

,

sezary syndrome

,

colonic diseases

,

histiocytic sarcoma

,

follicular dendritic cell sarcoma

,

interdigitating dendritic cell sarcoma

,

myeloproliferative disorders

,

essential thrombocythemia

,

polycythemia vera

,

primary myelofibrosis

,

,

,

intestinal neoplasms

,

nerve tissue neoplasms

,

neuroepithelial neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

carcinoid tumor

,

parotid neoplasms

,

,

,

alphapapillomavirus

,

nasopharyngeal diseases

,

aortic dissection

,

papillomaviridae

,

,

respiratory tract infections

,

disorders of sex development

,

,

,

extranodal extension

,

superior vena cava syndrome

,

gastrointestinal microbiome

,

,

ampulla of vater cancer

,

rheumatoid arthritis

,

ulcerative colitis

,

,

,

laryngeal diseases

,

alopecia areata

,

,

graft vs host disease

,

heavy ion radiotherapy

,

fertility preservation

,

adjuvant radiotherapy

,

male breast neoplasms

,

,

intraoperative complications

,

,

,

,

hemangioblastoma

,

sertoli-leydig cell tumor

,

endodermal sinus tumor

,

granulosa cell tumor

,

,

,

,

maintenance chemotherapy

,

maxillary sinus neoplasms

,

hyperthermic intraperitoneal chemotherapy

,

liver neoplasms

,

colorectal neoplasms

,

squamous cell carcinoma

,

neoplasm metastasis

,

renal cell carcinoma

,

triple negative breast neoplasms

,

pancreatic neoplasms

,

esophageal squamous cell carcinoma

,

head and neck neoplasms

,

uterine cervical neoplasms

,

small cell lung carcinoma

,

nasopharyngeal carcinoma

,

ovarian neoplasms

,

rectal neoplasms

,

urinary bladder neoplasms

,

,

endometrial neoplasms

,

urologic neoplasms

,

prostatic neoplasms

,

squamous cell neoplasms

,

cholangiocarcinoma

,

transitional cell carcinoma

,

large b-cell lymphoma diffuse

,

cutaneous malignant melanoma

,

neoadjuvant therapy

,

ovarian epithelial carcinoma

,

,

merkel cell carcinoma

,

,

kidney neoplasms

,

colonic neoplasms

,

brain neoplasms

,

microsatellite instability

,

fallopian tube neoplasms

,

multiple myeloma

,

malignant mesothelioma

,

,

,

,

myeloid leukemia acute

,

neuroendocrine tumors

,

healthy volunteers/patients

,

hematologic neoplasms

,

gallbladder neoplasms

,

plasma cell neoplasms

,

chemoradiotherapy

,

bile duct neoplasms

,

myeloid leukemia

,

,

uveal neoplasms

,

thoracic neoplasms

,

peritoneal neoplasms

,

hypopharyngeal neoplasms

,

,

hypersensitivity

,

,

laryngeal neoplasms

,

neoplasms by site

,

non-muscle invasive bladder neoplasms

,

uterine neoplasms

,

bronchogenic carcinoma

,

neoplasms by histologic type

,

molecular targeted therapy

,

respiratory tract neoplasms

,

mullerian mixed tumor

,

respiratory tract diseases

,

esophageal diseases

,

transplantation

,

germ cell and embryonal neoplasms

,

hereditary nonpolyposis colorectal neoplasms

,

pathologic complete response

,

gastrointestinal diseases

,

bronchial neoplasms

,

neuroectodermal tumors

,

large cell carcinoma

,

primitive neuroectodermal tumors

,

,

,

,

,

radiation pneumonitis

,

human herpesvirus 4

,

,

non-small-cell lung carcinoma

,

,

,

,

hepatocellular carcinoma

,

squamous cell carcinoma of head and neck

,

stomach neoplasms

,

breast neoplasms

,

,

,

nasopharyngeal neoplasms

,

esophageal neoplasms

,

,

hodgkin disease

,

biliary tract neoplasms

,

,

t-cell lymphoma

,

non-hodgkin lymphoma

,

t-cell lymphoma peripheral

,

thyroid neoplasms

,

,

thyroid diseases

,

epstein-barr virus infections

,

hemophagocytic lymphohistiocytosis

,

autoimmune diseases

,

,

interstitial lung diseases

,

,

,

parkinsonian disorders

,

,

rem sleep behavior disorder

,

mental disorders

,

alzheimer disease

,

neurodegenerative diseases

,

progressive supranuclear palsy

,

,

positron-emission tomography

,

nerve degeneration

,

tumor microenvironment

,

,

,

human influenza

,

,

,

cognitive dysfunction

,

corticobasal degeneration

,

pure autonomic failure

,

wounds and injuries

,

obstructive sleep apnea

,

sleep apnea syndromes

,

sleep wake disorders

,

normal pressure hydrocephalus

,

atherosclerotic plaque

,

graft rejection

,

carotid stenosis

,

cardiovascular diseases

,

cardiomyopathies

,

,

,

high-throughput nucleotide sequencing

,

,

endocrine system diseases

,

,

deglutition disorders

,

,

double-stranded dna breaks

,

,

gaucher disease

,

insulin resistance

,

cardiovascular abnormalities

,

rheumatic diseases

,

collagen diseases

,

pleural effusion

,

chromosomal instability

,

circulating neoplastic cells

,

,

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

,

,

,

,

,

,

,

orthostatic hypotension

,

movement disorders

,

magnetic resonance imaging

,

x-ray computed tomography

,

,

speech intelligibility

,

,

bcr-abl positive chronic myelogenous leukemia

,

transplantation chimera

,

diabetes mellitus

,

type 1 diabetes mellitus

,

,

ischemic stroke

,

,

,

,

,

immune system diseases

,

,

neurologic manifestations

,

,

nervous system heredodegenerative disorders

,

,

,

carotid intima-media thickness

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

irritable bowel syndrome

,

invasive fungal infections

,

catheter ablation

,

chemical and drug induced liver injury

,

sensitivity and specificity

,

dysplastic nevus syndrome

,

hereditary sensory and autonomic neuropathies

,

,

immunologic cytotoxicity

,

collective efficacy

,

,

phaeohyphomycosis

,

,

,

sinus arrhythmia

,

cardiac arrhythmias

,

amyotrophic lateral sclerosis

,

frontotemporal dementia

,

tdp-43 proteinopathies

,

,

neurocognitive disorders

,

,

circadian rhythm sleep disorders

,

,

electroacupuncture

,

hypercholesterolemia

,

healthy volunteers/patients

esophageal neoplasms

,

,

breast neoplasms

,

,

,

,

,

macular degeneration

,

hepatocellular carcinoma

non-hodgkin lymphoma

,

,

b-cell lymphoma

castleman disease

,

,

allergic rhinitis

,

,

allergic conjunctivitis

,

liver neoplasms

,

atopic dermatitis

,

,

neoplasm metastasis

,

healthy volunteers/patients

,

,

prostatic neoplasms

,

,

,

,

esophageal neoplasms

,

postoperative nausea and vomiting

,

brain neoplasms

,

second primary neoplasms

,

,

treatment-resistant depressive disorder

,

depressive disorder

,

esophageal squamous cell carcinoma

,

hematologic neoplasms

,

,

pseudomonas infections

,

pseudomonas aeruginosa

,

,

renal cell carcinoma

,

liver cirrhosis

,

experimental liver cirrhosis

,

chronic obstructive pulmonary disease

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

,

colorectal neoplasms

,

pancreatic ductal carcinoma

,

gastrointestinal neoplasms

,

biliary tract neoplasms

,

non-muscle invasive bladder neoplasms

,

non-small-cell lung carcinoma

,

,

,

acquired immunodeficiency syndrome

,

,

ovarian neoplasms

,

triple negative breast neoplasms

,

breast neoplasms

,

uterine cervical neoplasms

,

condylomata acuminata

,

,

hepatocellular carcinoma

,

,

immunologic deficiency syndromes

,

,

antibiotic prophylaxis

,

,

chronic hepatitis b

,

ovarian epithelial carcinoma

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

,

cystic fibrosis

,

pulmonary hypertension

,

pulmonary arterial hypertension

,

endometrial neoplasms

,

fallopian tube neoplasms

,

,

chronic hepatitis c

,

,

,

,

,

neuromuscular blockade

,

chronic kidney failure

,

kidney diseases

,

chronic hepatitis

,

intestinal diseases

,

,

non-hodgkin lymphoma

,

,

,

traumatic brain injuries

,

brain concussion

,

,

post-concussion syndrome

,

papillomavirus infections

,

uterine cervical dysplasia

healthy volunteers/patients

,

,

central nervous system neoplasms

,

nephrotic syndrome

,

laryngeal diseases

,

chronic hepatitis

,

,

esophageal neoplasms

,

postmenopausal osteoporosis

,

,

irritable bowel syndrome

,

pathologic dilatation

,

germ cell and embryonal neoplasms

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

oligodendroglioma

,

primitive neuroectodermal tumors

,

,

,

neuroepithelial neoplasms

,

hypertrophic pyloric stenosis

,

ganglioneuroblastoma

,

phenylketonurias

,

neuroendocrine tumors

,

b-cell lymphoma marginal zone

,

male breast neoplasms

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

rectal diseases

,

gastrointestinal diseases

,

intestinal neoplasms

,

digestive system diseases

,

colonic diseases

,

intestinal diseases

,

autism spectrum disorder

,

drug hypersensitivity

,

renal cell carcinoma

,

,

,

squamous cell carcinoma of head and neck

,

head and neck neoplasms

,

b-cell lymphoma

,

squamous cell carcinoma

,

,

large b-cell lymphoma diffuse

,

pancreatic ductal carcinoma

,

,

uveal neoplasms

,

,

lymphoid leukemia

,

mantle-cell lymphoma

,

myocardial infarction

,

kidney neoplasms

,

myelodysplastic syndromes

,

endometrial neoplasms

,

bronchiolitis obliterans syndrome

,

hypersensitivity

,

,

squamous cell neoplasms

,

waldenstrom macroglobulinemia

,

myeloid leukemia acute

,

multiple myeloma

,

castration-resistant prostatic neoplasms

,

hypertrophic cardiomyopathy

,

acute coronary syndrome

,

myocardial ischemia

,

unstable angina

,

margins of excision

,

hereditary sensory and autonomic neuropathies

,

gouty arthritis

,

gastrointestinal stromal tumors

,

,

,

retinitis pigmentosa

,

,

,

,

,

coronary artery disease

,

,

portal hypertension

,

atopic dermatitis

,

,

,

,

peritoneal neoplasms

,

intestinal obstruction

,

invasive hydatidiform mole

,

central serous chorioretinopathy

,

,

epstein-barr virus infections

,

oropharyngeal neoplasms

,

hodgkin disease

,

type 1 diabetes mellitus

,

,

neurofibrosarcoma

,

transitional cell carcinoma

,

ovarian neoplasms

,

fallopian tube neoplasms

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

netherton syndrome

,

,

eosinophilic esophagitis

,

,

systemic mastocytosis

,

mast-cell leukemia

,

,

,

female infertility

,

sickle cell anemia

,

streptococcus agalactiae

,

angioid streaks

,

pseudoxanthoma elasticum

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

microscopic polyangiitis

,

diffuse scleroderma

,

t-cell lymphoma

,

malignant mesothelioma

,

clear cell adenocarcinoma

,

,

adenomyoepithelioma

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

myeloid leukemia

,

,

triple negative breast neoplasms

,

prostatic neoplasms

,

,

,

follicular lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

cardiovascular diseases

,

graft vs host disease

,

,

psoriatic arthritis

,

,

rheumatoid arthritis

,

meningococcal meningitis

,

meningococcal infections

,

hypercholesterolemia

,

rectal neoplasms

,

osteitis deformans

,

,

philadelphia chromosome

,

degenerative myopia

,

non-hodgkin lymphoma

,

stomach neoplasms

,

,

neoplasms by site

,

inferior wall myocardial infarction

,

,

psychology rejection

,

organ transplantation

,

graft rejection

,

adenocarcinoma of lung

,

,

aplastic anemia

,

,

carcinoid tumor

,

,

chronic hepatitis c

,

lupus nephritis

,

,

colonic neoplasms

,

retinopathy of prematurity

,

polycythemia vera

,

,

,

,

hematologic neoplasms

,

neoplasms by histologic type

,

left ventricular dysfunction

,

st elevation myocardial infarction

,

non-st elevated myocardial infarction

,

,

,

,

infectious skin diseases

,

soft tissue infections

,

,

malignant carcinoid syndrome

,

serotonin syndrome

,

erectile dysfunction

,

peanut hypersensitivity

,

allergic rhinitis seasonal

,

,

,

haemophilus infections

,

,

cerebrotendinous xanthomatosis

,

,

muscular atrophy

,

spinal muscular atrophy

,

,

neovascular glaucoma

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

chronic obstructive pulmonary disease

,

,

alpha 1-antitrypsin deficiency

,

lymphoproliferative disorders

,

,

breast neoplasms

,

,

macular degeneration

,

,

,

,

kidney transplantation

,

vision disorders

,

choroidal neovascularization

,

type 2 diabetes mellitus

,

neoplasm metastasis

,

retinal vein occlusion

,

chronic urticaria

,

diabetes mellitus

,

liver transplantation

,

essential hypertension

,

multiple sclerosis

,

diabetic retinopathy

,

kidney diseases

,

brain neoplasms

,

relapsing-remitting multiple sclerosis

,

metabolic syndrome

,

renal insufficiency

,

,

pancreatic neoplasms

,

,

chronic kidney failure

,

,

retinal diseases

,

systolic heart failure

,

insulin resistance

,

,

geographic atrophy

,

parkinson disease

,

diastolic heart failure

,

chronic renal insufficiency

,

,

diabetic nephropathies

,

wet macular degeneration

,

,

,

retinal neovascularization

,

polypoidal choroidal vasculopathy

,

liver cirrhosis

,

,

diabetes complications

,

isolated systolic hypertension

,

systolic murmurs

,

,

left ventricular hypertrophy

,

,

glucose intolerance

,

,

chronic progressive multiple sclerosis

,

,

,

membranous glomerulonephritis

,

,

,

pathologic neovascularization

,

tick-borne encephalitis

,

,

,

,

renal replacement therapy

,

,

prehypertension

,

,

staphylococcal skin infections

,

,

,

neurobehavioral manifestations

,

heart transplantation

,

pituitary acth hypersecretion

,

cystic fibrosis

,

allergic bronchopulmonary aspergillosis

,

,

pituitary neoplasms

,

,

sexual infantilism

,

heart-lung transplantation

,

,

coronavirus infections

,

,

polyomavirus infections

,

retinal detachment

,

atrial fibrillation

,

iga glomerulonephritis

,

focal segmental glomerulosclerosis

,

nephrosclerosis

,

allergic conjunctivitis

,

reperfusion injury

,

delayed graft function

,

food hypersensitivity

,

islet cell adenoma

,

metabolic bone diseases

,

cryopyrin-associated periodic syndromes

,

,

,

,

immunosuppression therapy

,

angina pectoris

,

microvascular angina

,

spinal muscular atrophies of childhood

,

hematopoietic stem cell transplantation

pancreatic ductal carcinoma

,

pancreatic neoplasms

,

,

urologic neoplasms

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

Pegvorhyaluronidase alfa

non-small-cell lung carcinoma

,

cholangiocarcinoma

,

,

stomach neoplasms

,

pancreatic neoplasms

,

,

esophageal neoplasms

,

breast neoplasms

,

,

pancreatic ductal carcinoma

,

ductal carcinoma

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