Halozyme Therapeutics - PharmaKB

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Company ReportsHalozyme Therapeutics

Halozyme Therapeutics(HALO)

Halozyme Therapeutics is an American biotechnology company that develops novel oncology therapies designed to target the tumor microenvironment and licenses a novel drug delivery technology through corporate partnerships.

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Hylenex recombinant	Hyaluronidase (human recombinant)	2005-12-02		Rheumatoid arthritis , Mantle-cell lymphoma , B-cell lymphoma , Lymphoid leukemia , Granulomatosis with polyangiitis , Microscopic polyangiitis

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Hyaluronidase (human recombinant)

non-hodgkin lymphoma

,

b-cell lymphoma

,

multiple myeloma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

prostatic neoplasms

,

breast neoplasms

,

ovarian neoplasms

,

pancreatic neoplasms

,

,

,

cutaneous malignant melanoma

,

non-small-cell lung carcinoma

,

Hyaluronate sodium

,

knee osteoarthritis

,

,

cartilage diseases

,

,

tibial meniscus injuries

,

patellofemoral pain syndrome

,

Polytetrafluoroethylene

ovarian neoplasms

,

kidney neoplasms

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

hematologic diseases

,

myelomonocytic leukemia chronic

,

myeloid leukemia

,

myelomonocytic leukemia juvenile

,

,

bone marrow diseases

,

,

gastrointestinal stromal tumors

,

,

multiple myeloma

,

plasma cell neoplasms

,

alveolar soft part sarcoma

,

,

head and neck neoplasms

,

colonic neoplasms

,

rectal neoplasms

,

,

intestinal neoplasms

,

thymus neoplasms

,

,

non-small-cell lung carcinoma

,

colorectal neoplasms

,

triple negative breast neoplasms

,

,

hepatocellular carcinoma

,

renal cell carcinoma

,

,

liver neoplasms

,

,

breast neoplasms

,

ovarian epithelial carcinoma

,

,

squamous cell carcinoma of head and neck

,

,

small cell lung carcinoma

,

,

squamous cell neoplasms

,

,

pancreatic ductal carcinoma

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

pancreatic neoplasms

,

esophageal neoplasms

,

squamous cell carcinoma

,

esophageal squamous cell carcinoma

,

clear cell adenocarcinoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

neuroendocrine tumors

,

urologic neoplasms

,

thyroid neoplasms

,

uterine cervical neoplasms

,

cholangiocarcinoma

,

unknown primary neoplasms

,

adenocarcinoma of lung

,

,

uveal neoplasms

,

adenomyoepithelioma

,

,

neoplasm metastasis

,

hematologic neoplasms

,

anaplastic thyroid carcinoma

,

malignant mesothelioma

,

neuroendocrine carcinoma

,

,

healthy volunteers/patients

,

metabolic diseases

,

metabolic syndrome

,

lipid metabolism disorders

,

hypercholesterolemia

,

,

hyperlipidemias

,

hyperlipoproteinemias

,

cardiovascular diseases

,

hyperlipoproteinemia type ii

,

,

healthy volunteers/patients

,

diabetes mellitus

,

,

healthy volunteers/patients

,

,

subarachnoid hemorrhage

,

,

von willebrand diseases

,

ulcerative colitis

,

hodgkin disease

,

,

cytomegalovirus

,

,

primary myelofibrosis

,

,

precocious puberty

,

type 2 diabetes mellitus

,

healthy volunteers/patients

,

,

central nervous system neoplasms

,

nephrotic syndrome

,

laryngeal diseases

,

,

chronic hepatitis

,

,

,

esophageal neoplasms

,

postmenopausal osteoporosis

,

,

irritable bowel syndrome

,

pathologic dilatation

,

germ cell and embryonal neoplasms

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

oligodendroglioma

,

primitive neuroectodermal tumors

,

,

,

neuroepithelial neoplasms

,

hypertrophic pyloric stenosis

,

ganglioneuroblastoma

,

phenylketonurias

,

neuroendocrine tumors

,

b-cell lymphoma marginal zone

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

rectal diseases

,

gastrointestinal diseases

,

intestinal neoplasms

,

digestive system diseases

,

colonic diseases

,

intestinal diseases

,

autism spectrum disorder

,

drug hypersensitivity

,

renal cell carcinoma

,

,

,

squamous cell carcinoma of head and neck

,

b-cell lymphoma

,

head and neck neoplasms

,

squamous cell carcinoma

,

large b-cell lymphoma diffuse

,

pancreatic ductal carcinoma

,

,

,

uveal neoplasms

,

,

mantle-cell lymphoma

,

multiple myeloma

,

myocardial infarction

,

kidney neoplasms

,

hereditary sensory and autonomic neuropathies

,

myelodysplastic syndromes

,

endometrial neoplasms

,

bronchiolitis obliterans syndrome

,

coronary artery disease

,

hypersensitivity

,

philadelphia chromosome

,

lymphoid leukemia

,

,

squamous cell neoplasms

,

waldenstrom macroglobulinemia

,

myeloid leukemia acute

,

castration-resistant prostatic neoplasms

,

hypertrophic cardiomyopathy

,

acute coronary syndrome

,

myocardial ischemia

,

unstable angina

,

margins of excision

,

gouty arthritis

,

gastrointestinal stromal tumors

,

,

,

retinitis pigmentosa

,

,

,

,

,

portal hypertension

,

atopic dermatitis

,

,

,

,

peritoneal neoplasms

,

intestinal obstruction

,

invasive hydatidiform mole

,

central serous chorioretinopathy

,

,

epstein-barr virus infections

,

oropharyngeal neoplasms

,

hodgkin disease

,

type 1 diabetes mellitus

,

,

neurofibrosarcoma

,

ovarian neoplasms

,

fallopian tube neoplasms

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

netherton syndrome

,

,

eosinophilic esophagitis

,

,

systemic mastocytosis

,

mast-cell leukemia

,

,

,

female infertility

,

sickle cell anemia

,

streptococcus agalactiae

,

angioid streaks

,

pseudoxanthoma elasticum

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

microscopic polyangiitis

,

diffuse scleroderma

,

immune system diseases

,

t-cell lymphoma

,

malignant mesothelioma

,

lymphatic diseases

,

immunoproliferative disorders

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

,

myeloid leukemia

,

triple negative breast neoplasms

,

,

prostatic neoplasms

,

follicular lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

non-hodgkin lymphoma

,

cardiovascular diseases

,

hypercholesterolemia

,

graft vs host disease

,

,

psoriatic arthritis

,

,

rheumatoid arthritis

,

meningococcal meningitis

,

meningococcal infections

,

neoplasms by site

,

rectal neoplasms

,

osteitis deformans

,

,

degenerative myopia

,

stomach neoplasms

,

,

neoplasms by histologic type

,

inferior wall myocardial infarction

,

,

psychology rejection

,

organ transplantation

,

graft rejection

,

adenocarcinoma of lung

,

,

aplastic anemia

,

,

carcinoid tumor

,

,

chronic hepatitis c

,

lupus nephritis

,

,

colonic neoplasms

,

retinopathy of prematurity

,

polycythemia vera

,

male breast neoplasms

,

,

,

,

lymphoproliferative disorders

,

hematologic neoplasms

,

left ventricular dysfunction

,

st elevation myocardial infarction

,

non-st elevated myocardial infarction

,

,

,

,

infectious skin diseases

,

soft tissue infections

,

,

malignant carcinoid syndrome

,

serotonin syndrome

,

erectile dysfunction

,

peanut hypersensitivity

,

allergic rhinitis seasonal

,

,

,

haemophilus infections

,

,

cerebrotendinous xanthomatosis

,

,

muscular diseases

,

muscular atrophy

,

spinal muscular atrophy

,

x-linked bulbo-spinal atrophy

,

neovascular glaucoma

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

chronic obstructive pulmonary disease

,

,

alpha 1-antitrypsin deficiency

,

primary myelofibrosis

,

progressive supranuclear palsy

,

pick disease of the brain

,

,

breast neoplasms

,

,

macular degeneration

,

,

,

,

kidney transplantation

,

vision disorders

,

choroidal neovascularization

,

type 2 diabetes mellitus

,

neoplasm metastasis

,

retinal vein occlusion

,

chronic urticaria

,

diabetes mellitus

,

liver transplantation

,

essential hypertension

,

multiple sclerosis

,

diabetic retinopathy

,

kidney diseases

,

brain neoplasms

,

relapsing-remitting multiple sclerosis

,

metabolic syndrome

,

renal insufficiency

,

,

pancreatic neoplasms

,

,

chronic kidney failure

,

,

retinal diseases

,

systolic heart failure

,

,

insulin resistance

,

,

geographic atrophy

,

parkinson disease

,

diastolic heart failure

,

chronic renal insufficiency

,

,

diabetic nephropathies

,

wet macular degeneration

,

,

,

retinal neovascularization

,

polypoidal choroidal vasculopathy

,

liver cirrhosis

,

,

diabetes complications

,

isolated systolic hypertension

,

systolic murmurs

,

left ventricular hypertrophy

,

,

glucose intolerance

,

,

chronic progressive multiple sclerosis

,

membranous glomerulonephritis

,

,

,

pathologic neovascularization

,

tick-borne encephalitis

,

,

,

,

renal replacement therapy

,

,

prehypertension

,

,

staphylococcal skin infections

,

,

,

neurobehavioral manifestations

,

heart transplantation

,

pituitary acth hypersecretion

,

cystic fibrosis

,

allergic bronchopulmonary aspergillosis

,

,

pituitary neoplasms

,

,

sexual infantilism

,

heart-lung transplantation

,

,

coronavirus infections

,

polyomavirus infections

,

retinal detachment

,

atrial fibrillation

,

iga glomerulonephritis

,

focal segmental glomerulosclerosis

,

nephrosclerosis

,

allergic conjunctivitis

,

reperfusion injury

,

delayed graft function

,

food hypersensitivity

,

islet cell adenoma

,

metabolic bone diseases

,

cryopyrin-associated periodic syndromes

,

,

,

,

immunosuppression therapy

,

angina pectoris

,

microvascular angina

,

spinal muscular atrophies of childhood

,

hematopoietic stem cell transplantation

,

secondary prevention

,

glomerulonephritis

,

colorectal neoplasms

healthy volunteers/patients

,

,

pheochromocytoma

,

neuroendocrine tumors

,

,

meningeal carcinomatosis

,

,

laryngeal neoplasms

,

pancreatic ductal carcinoma

,

,

head and neck neoplasms

,

squamous cell neoplasms

,

transitional cell carcinoma

,

malignant pleural effusion

,

fallopian tube neoplasms

,

small cell carcinoma

,

psychological inhibition

,

gastrointestinal neoplasms

,

dna repair-deficiency disorders

,

urinary bladder neoplasms

,

salivary gland neoplasms

,

,

,

radiation injuries

,

radiation effects

,

germ cell and embryonal neoplasms

,

peritoneal neoplasms

,

,

pleural effusion

,

,

residual neoplasm

,

breast neoplasms

,

type 2 diabetes mellitus

,

neoplasm metastasis

,

diabetes mellitus

,

,

,

prostatic neoplasms

,

,

,

small cell lung carcinoma

,

triple negative breast neoplasms

,

gastroesophageal reflux

,

,

,

,

,

rheumatoid arthritis

,

castration-resistant prostatic neoplasms

,

ovarian neoplasms

,

neoplasms by site

,

,

major depressive disorder

,

depressive disorder

,

,

peptic esophagitis

,

,

colorectal neoplasms

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

renal cell carcinoma

,

endometrial neoplasms

,

stomach neoplasms

,

,

,

hepatocellular carcinoma

,

liver neoplasms

,

urologic neoplasms

,

,

,

chronic renal insufficiency

,

kidney diseases

,

,

cardiovascular diseases

,

pancreatic neoplasms

,

ovarian epithelial carcinoma

,

breast diseases

,

sickle cell anemia

,

brain neoplasms

,

,

,

opioid-induced constipation

,

,

hypercholesterolemia

,

biliary tract neoplasms

,

gallbladder neoplasms

,

disease progression

,

hereditary breast and ovarian cancer syndrome

,

,

,

,

glucose metabolism disorders

,

metabolic diseases

,

endocrine system diseases

,

hypersensitivity

,

,

kidney neoplasms

,

,

zollinger-ellison syndrome

,

,

peptic ulcer hemorrhage

,

,

,

chronic obstructive pulmonary disease

,

obstructive lung diseases

,

,

anxiety disorders

,

,

venous thrombosis

,

pulmonary embolism

,

plexiform neurofibroma

,

neurofibromatosis 1

,

unknown primary neoplasms

,

respiratory insufficiency

,

myocardial infarction

,

coronary artery disease

,

bile duct neoplasms

,

cholangiocarcinoma

,

,

respiratory syncytial virus infections

,

uterine neoplasms

,

b-cell lymphoma

,

esophageal neoplasms

,

non-small-cell lung carcinoma

,

,

,

respiratory tract diseases

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

bronchial neoplasms

Pegvorhyaluronidase alfa

non-small-cell lung carcinoma

,

cholangiocarcinoma

,

,

stomach neoplasms

,

pancreatic neoplasms

,

,

esophageal neoplasms

,

breast neoplasms

,

pancreatic ductal carcinoma

,

,

ductal carcinoma

,

thromboembolism

Polyglycolic acid

,

rectal neoplasms

,

pancreatic neoplasms

,

,

neoplasm metastasis

,

esophageal neoplasms

,

stomach neoplasms

,

colonic neoplasms

,

colorectal neoplasms

,

rheumatoid arthritis

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